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In the Eighties parenteral steroids had been used to treat patients with DSS in severalcountries. The use of intravenous steroid injections in this setting has become a major health concern in recent years. How Is Cystine Used? In clinical cases, patients are treated with low-dose parenteral steroids that contain cystine for 10 to 24 hours. Usually, a short-acting parenteral steroid, such as hydroxychloroquine, will be the least preferred because severe effects of the steroid are expected to begin within 24 hours. For parenteral steroid injections, a low-dose of cystine can be given directly into the thigh or through subcutaneous lines. Most patients will require injection into the thigh, although an oral solution of cystine is often effective in parenteral injections. If desired, cystine may also be provided as a solution in a sterile syringe. In general, patients are given about 4 to 5 mg of cystine per ml of patient blood for every milliliter of whole blood, in doses of 10 to 20 mg/ml. If the patient has more than one syringe, they will need to take a total of 40 to 60 tablets (two to 20 mg/ml), divided into two doses. Dosing and administration rates are based on weight rather than sex. For obese patients, an average of 60 to 70 mg/ml of cystine should be given, based on weight; for normal-range weight patients, a typical daily dose would be 25 to 35 mg/ml. The maximum daily dose is 40 mg/ml for men and 20 mg/ml for women. Treatment and Adverse Consequences A variety of symptoms are reported following cystine treatment, including: Headache Tremor Weight loss Dizziness Nausea Muscle aches Anorexia Seizures Heart palpitation Nasal congestion Muscle weakness Insomnia Skin flushing The potential for serious gastrointestinal complications is usually avoided because of the high concentration of cystine, which is less concentrated in the mucous membranes of the gastrointestinal tract. Although symptoms and adverse consequences may be mild, they may worsen with repeated treatment. The main potential adverse consequences of cystine treatment are: Severe adverse reactions are rare in untreated cases. However, in severely disabled patients, cystine might be a Similar articles:
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